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Gut–vagus knowledge graph — peptide/receptor seed.
A curated rank-only reference seed for the gut–vagus peptide/receptor axis, with full inventories deferred to external atlases.
Engine 1 · gut–vagus knowledge graph
A curated, evidence-noted seed — not a claim to have every peptide.
The knowledge graph links peptides across source universes to receptors, vagal relevance, and delivery liabilities. What ships today is a small, curated reference seed where every entry carries its evidence basis. The full inventories live in public databases (PeptideAtlas, BIOPEP-UWM, DFBP, NeuroPep, FermFooDb) and fold in only with license and provenance review. It is rank-only reference data, not a predictor.
Source universes (kept separate)
7
Human / endogenous
oxytocin, GLP-1, PYY, CCK-8, neurotensin, ghrelin, somatostatin
2
Food-derived
milk casein lactotripeptides (IPP, VPP)
2
Fungal
cyclosporine, echinocandin (caspofungin)
2
Approved drug
semaglutide, octreotide
Gut–vagus receptor atlas
OXTRprimary vagal afferent
GLP1Rprimary vagal afferent
CCKARprimary vagal afferent
NPY2Rprimary vagal afferent
NTSR1primary vagal afferent
GHSRprimary vagal afferent
SSTR2secondary (via gut)
Primary = receptor on vagal afferent neurons (vagal-afferent GPCR profiling; OXTR per a 2025 vagus study). Secondary = acts on gut cells that then signal the vagus. Source:
Packages/PeptiterDiscovery/…/PeptideKnowledgeGraph.swift.More on platform
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Agent-facing operational surface.
Architecture
System layers and contracts.
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Modalities and enforced claim discipline.
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Snapshot
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Safety
Research-use boundaries.
Demo
Final call to action.
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