Natural seeds — parent peptide library and guardrails.
The natural-seed library and its guardrails — DiscoveryLab generates around evolved peptide families, not from a blank slate.
Endogenous and animal peptides now seed bounded analog discovery.
DiscoveryLab can start from curated parent peptides such as GLP-1, exendin-4, GIP, PYY, somatostatin, salmon calcitonin, LL-37, hepcidin, and ziconotide lineage scaffolds, then stabilize or evolve variants under explicit evidence guardrails.
The Swift agent runner starts one constrained discovery loop per parent peptide, records ancestry on every candidate, and blocks mechanism-only systems until a curated peptide sequence or motif bridge exists.
Direct mutation is enabled only for seeds with a recorded sequence.
Dsup, bear hibernation, and antifreeze biology are mechanism inspiration, not drug claims.
Natural origin never implies safety, dose, efficacy, or clinical readiness.
Every generated family still needs fit, stability, synthesis, toxicity, and mechanism gates.
The first default run completed all nine seed-scoped agents and retained a six-candidate Pareto panel for each lineage. These are computational hypotheses only; every row still requires folding, receptor-fit, stability, synthesis, and safety evidence before promotion language.